Slowing of high-speed memory scanning in Parkinson's disease is related to the severity of parkinsonian motor symptoms
Identifieur interne : 000817 ( Main/Corpus ); précédent : 000816; suivant : 000818Slowing of high-speed memory scanning in Parkinson's disease is related to the severity of parkinsonian motor symptoms
Auteurs : G. Ransmayr ; W. Bitschnau ; B. Schmidhuber-Eiler ; W. Berger ; E. Karamat ; W. Poewe ; W. KemmlerSource :
- Journal of Neural Transmission - Parkinson's Disease and Dementia Section [ 0936-3076 ] ; 1990-12-01.
Abstract
Summary: High-speed memory scanning (Sternberg paradigm) was tested in a collective of 20 parkinsonian patients (10 newly diagnosed, untreated patients, duration of the disease 0.5–3.8, mean 1.5 years; 10 levodopa-treated patients, duration of the disease 4.2 to 11, mean 7.6 years). The levodopa-treated patients stopped taking levodopa before the test. There was a tendency towards retarded memory scanning in the patients' collective compared with 20 healthy controls with similar ages and verbal IQs (p=0.076, Mann-Whitney U test). The mental slowing correlated significantly with bradykinesia and the sum-score of the Columbia University Parkinson Rating Scale (p=0.021 and 0.019; Spearman rank correlation). Kruskal-Wallis ANOVA revealed a significant mental slowing in the subgroup of patients with Parkinson's disease for >4 years compared with the newly diagnosed patients and the controls (H=8.54; p=0.019 and 0.006, Mann-Whitney U test). The findings suggest a mental slowing in Parkinson's disease, which is associated with the progression of parkinsonian motor symptoms and not with depression.
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DOI: 10.1007/BF02252921
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The levodopa-treated patients stopped taking levodopa before the test. There was a tendency towards retarded memory scanning in the patients' collective compared with 20 healthy controls with similar ages and verbal IQs (p=0.076, Mann-Whitney U test). The mental slowing correlated significantly with bradykinesia and the sum-score of the Columbia University Parkinson Rating Scale (p=0.021 and 0.019; Spearman rank correlation). Kruskal-Wallis ANOVA revealed a significant mental slowing in the subgroup of patients with Parkinson's disease for >4 years compared with the newly diagnosed patients and the controls (H=8.54; p=0.019 and 0.006, Mann-Whitney U test). The findings suggest a mental slowing in Parkinson's disease, which is associated with the progression of parkinsonian motor symptoms and not with depression.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>Dr. G. Ransmayr</name><affiliations><json:string>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>W. Bitschnau</name><affiliations><json:string>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>B. Schmidhuber-Eiler</name><affiliations><json:string>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>W. Berger</name><affiliations><json:string>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>E. Karamat</name><affiliations><json:string>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>W. Poewe</name><affiliations><json:string>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>G. W. 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The mental slowing correlated significantly with bradykinesia and the sum-score of the Columbia University Parkinson Rating Scale (p=0.021 and 0.019; Spearman rank correlation). Kruskal-Wallis ANOVA revealed a significant mental slowing in the subgroup of patients with Parkinson's disease for >4 years compared with the newly diagnosed patients and the controls (H=8.54; p=0.019 and 0.006, Mann-Whitney U test). The findings suggest a mental slowing in Parkinson's disease, which is associated with the progression of parkinsonian motor symptoms and not with depression.</abstract><qualityIndicators><score>5.943</score><pdfVersion>1.3</pdfVersion><pdfPageSize>576 x 774 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1107</abstractCharCount><pdfWordCount>4059</pdfWordCount><pdfCharCount>24881</pdfCharCount><pdfPageCount>11</pdfPageCount><abstractWordCount>157</abstractWordCount></qualityIndicators><title>Slowing of high-speed memory scanning in Parkinson's disease is related to the severity of parkinsonian motor symptoms</title><genre><json:string>research-article</json:string></genre><host><volume>2</volume><pages><last>275</last><first>265</first></pages><issn><json:string>0936-3076</json:string></issn><issue>4</issue><subject><json:item><value>Pharmacology/Toxicology</value></json:item><json:item><value>Psychiatry</value></json:item><json:item><value>Neurology</value></json:item></subject><journalId><json:string>722</json:string></journalId><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1435-1463</json:string></eissn><title>Journal of Neural Transmission - 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Parkinson's Disease and Dementia Section</title><title level="j" type="abbrev">J Neural Transm Gen Sect</title><idno type="JournalID">722</idno><idno type="pISSN">0936-3076</idno><idno type="eISSN">1435-1463</idno><idno type="IssueArticleCount">9</idno><idno type="VolumeIssueCount">4</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1990-12-01"></date><biblScope unit="volume">2</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="265">265</biblScope><biblScope unit="page" to="275">275</biblScope></imprint></monogr><idno type="istex">20BE50ACC3D4B0C9DE226D7689165336DBD1B5E6</idno><idno type="DOI">10.1007/BF02252921</idno><idno type="ArticleID">Art3</idno><idno type="ArticleID">BF02252921</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990-03-16</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: High-speed memory scanning (Sternberg paradigm) was tested in a collective of 20 parkinsonian patients (10 newly diagnosed, untreated patients, duration of the disease 0.5–3.8, mean 1.5 years; 10 levodopa-treated patients, duration of the disease 4.2 to 11, mean 7.6 years). The levodopa-treated patients stopped taking levodopa before the test. There was a tendency towards retarded memory scanning in the patients' collective compared with 20 healthy controls with similar ages and verbal IQs (p=0.076, Mann-Whitney U test). The mental slowing correlated significantly with bradykinesia and the sum-score of the Columbia University Parkinson Rating Scale (p=0.021 and 0.019; Spearman rank correlation). Kruskal-Wallis ANOVA revealed a significant mental slowing in the subgroup of patients with Parkinson's disease for >4 years compared with the newly diagnosed patients and the controls (H=8.54; p=0.019 and 0.006, Mann-Whitney U test). The findings suggest a mental slowing in Parkinson's disease, which is associated with the progression of parkinsonian motor symptoms and not with depression.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Pharmacology/Toxicology</term></item><item><term>Psychiatry</term></item><item><term>Neurology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1990-03-16">Created</change><change when="1990-12-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-2">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/20BE50ACC3D4B0C9DE226D7689165336DBD1B5E6/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Vienna</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>722</JournalID><JournalPrintISSN>0936-3076</JournalPrintISSN><JournalElectronicISSN>1435-1463</JournalElectronicISSN><JournalTitle>Journal of Neural Transmission - Parkinson's Disease and Dementia Section</JournalTitle><JournalAbbreviatedTitle>J Neural Transm Gen Sect</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Type="Secondary">Pharmacology/Toxicology</JournalSubject><JournalSubject Type="Secondary">Psychiatry</JournalSubject><JournalSubject Type="Secondary">Neurology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>2</VolumeIDStart><VolumeIDEnd>2</VolumeIDEnd><VolumeIssueCount>4</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>4</IssueIDStart><IssueIDEnd>4</IssueIDEnd><IssueArticleCount>9</IssueArticleCount><IssueHistory><CoverDate><DateString>1990</DateString><Year>1990</Year><Month>12</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1990</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art3"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF02252921</ArticleID><ArticleDOI>10.1007/BF02252921</ArticleDOI><ArticleSequenceNumber>3</ArticleSequenceNumber><ArticleTitle Language="En">Slowing of high-speed memory scanning in Parkinson's disease is related to the severity of parkinsonian motor symptoms</ArticleTitle><ArticleCategory>Full Papers</ArticleCategory><ArticleFirstPage>265</ArticleFirstPage><ArticleLastPage>275</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>10</Month><Day>25</Day></RegistrationDate><Received><Year>1990</Year><Month>3</Month><Day>16</Day></Received><Accepted><Year>1990</Year><Month>7</Month><Day>4</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1990</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>722</JournalID><VolumeIDStart>2</VolumeIDStart><VolumeIDEnd>2</VolumeIDEnd><IssueIDStart>4</IssueIDStart><IssueIDEnd>4</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" PresentAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><Prefix>Dr.</Prefix><GivenName>G.</GivenName><FamilyName>Ransmayr</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>W.</GivenName><FamilyName>Bitschnau</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>B.</GivenName><FamilyName>Schmidhuber-Eiler</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>W.</GivenName><FamilyName>Berger</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>E.</GivenName><FamilyName>Karamat</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>W.</GivenName><FamilyName>Poewe</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>G.</GivenName><GivenName>W.</GivenName><FamilyName>Kemmler</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>University Clinic of Neurology</OrgDivision><OrgName>University of Innsbruck</OrgName><OrgAddress><Street>Anichstrasse 35</Street><Postcode>A-6020</Postcode><City>Innsbruck</City><Country>Austria</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Biostatistics</OrgDivision><OrgName>University of Innsbruck</OrgName><OrgAddress><Street>Anichstrasse 35</Street><Postcode>A-6020</Postcode><City>Innsbruck</City><Country>Austria</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>High-speed memory scanning (Sternberg paradigm) was tested in a collective of 20 parkinsonian patients (10 newly diagnosed, untreated patients, duration of the disease 0.5–3.8, mean 1.5 years; 10 levodopa-treated patients, duration of the disease 4.2 to 11, mean 7.6 years). The levodopa-treated patients stopped taking levodopa before the test. There was a tendency towards retarded memory scanning in the patients' collective compared with 20 healthy controls with similar ages and verbal IQs (p=0.076, Mann-Whitney U test). The mental slowing correlated significantly with bradykinesia and the sum-score of the Columbia University Parkinson Rating Scale (p=0.021 and 0.019; Spearman rank correlation). Kruskal-Wallis ANOVA revealed a significant mental slowing in the subgroup of patients with Parkinson's disease for >4 years compared with the newly diagnosed patients and the controls (H=8.54; p=0.019 and 0.006, Mann-Whitney U test). The findings suggest a mental slowing in Parkinson's disease, which is associated with the progression of parkinsonian motor symptoms and not with depression.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>High-speed memory scanning</Keyword><Keyword>Parkinson's disease</Keyword><Keyword>parkinsonian motor symptoms</Keyword><Keyword>levodopa treatment</Keyword><Keyword>depression</Keyword><Keyword>bradyphrenia</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Slowing of high-speed memory scanning in Parkinson's disease is related to the severity of parkinsonian motor symptoms</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Slowing of high-speed memory scanning in Parkinson's disease is related to the severity of parkinsonian motor symptoms</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">G.</namePart><namePart type="family">Ransmayr</namePart><affiliation>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Bitschnau</namePart><affiliation>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Schmidhuber-Eiler</namePart><affiliation>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Berger</namePart><affiliation>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Karamat</namePart><affiliation>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Poewe</namePart><affiliation>University Clinic of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="given">W.</namePart><namePart type="family">Kemmler</namePart><affiliation>Department of Biostatistics, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Vienna</placeTerm></place><dateCreated encoding="w3cdtf">1990-03-16</dateCreated><dateIssued encoding="w3cdtf">1990-12-01</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: High-speed memory scanning (Sternberg paradigm) was tested in a collective of 20 parkinsonian patients (10 newly diagnosed, untreated patients, duration of the disease 0.5–3.8, mean 1.5 years; 10 levodopa-treated patients, duration of the disease 4.2 to 11, mean 7.6 years). The levodopa-treated patients stopped taking levodopa before the test. There was a tendency towards retarded memory scanning in the patients' collective compared with 20 healthy controls with similar ages and verbal IQs (p=0.076, Mann-Whitney U test). The mental slowing correlated significantly with bradykinesia and the sum-score of the Columbia University Parkinson Rating Scale (p=0.021 and 0.019; Spearman rank correlation). Kruskal-Wallis ANOVA revealed a significant mental slowing in the subgroup of patients with Parkinson's disease for >4 years compared with the newly diagnosed patients and the controls (H=8.54; p=0.019 and 0.006, Mann-Whitney U test). The findings suggest a mental slowing in Parkinson's disease, which is associated with the progression of parkinsonian motor symptoms and not with depression.</abstract><note>Full Papers</note><relatedItem type="host"><titleInfo><title>Journal of Neural Transmission - Parkinson's Disease and Dementia Section</title></titleInfo><titleInfo type="abbreviated"><title>J Neural Transm Gen Sect</title></titleInfo><genre type="Journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1990-12-01</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Pharmacology/Toxicology</topic><topic>Psychiatry</topic><topic>Neurology</topic></subject><identifier type="ISSN">0936-3076</identifier><identifier type="eISSN">1435-1463</identifier><identifier type="JournalID">722</identifier><identifier type="IssueArticleCount">9</identifier><identifier type="VolumeIssueCount">4</identifier><part><date>1990</date><detail type="volume"><number>2</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="pages"><start>265</start><end>275</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1990</recordOrigin></recordInfo></relatedItem><identifier type="istex">20BE50ACC3D4B0C9DE226D7689165336DBD1B5E6</identifier><identifier type="DOI">10.1007/BF02252921</identifier><identifier type="ArticleID">Art3</identifier><identifier type="ArticleID">BF02252921</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1990</recordOrigin></recordInfo></mods></metadata><enrichments><istex:refBibTEI 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